Exercise. Yes, I know, you're working. But it's important to get up from the computer and stretch. I know it's tempting to throw in a load of laundry when taking a break at home, and that's a fine idea sometimes. But be careful not to let a quick around-the-house errand turn into an hour of housework. If you've got a spare hour, spend it getting some exercise to stay healthy and recharge your mind. I'm working on this.
Reach out. Set aside some time each week to reconnect with former and current coworkers and friends on social networks. Send a few emails to catch up and stay connected for those long stretches when getting out of the home office and connecting in person are not an option. I'm working ont this, too.
If you work from home, at least part of the time, what are your best survival tips for working from home without losing direction and valuable connections?